Azee 500mg (Azithromycin)

Azithromycin
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Cipla Ltd

Azee 500mg (Azithromycin)

ManufacturerCipla LtdActive substanceAzithromycinStrength500mgCategoryAnti BioticManufacturerCipla LtdPackaging30 Tablet

Description of Azee 500mg (Azithromycin 500mg)

Azee 500mg (Azithromycin 500mg) belongs to semi- synthetic macrolide antibiotic which fights against bacteria and its belongs to the class of Azalide. Azee 500mg (Azithromycin 500mg) is a white crystalline powder and as the dehydrate.

Medical use /Indication of Azee 500mg (Azithromycin 500mg)

Azee 500mg (Azithromycin 500mg) is also used to prevent disseminated Mycobacterium avium complex (MAC) infection
 Infection of the ears, lungs, sinuses, throat and reproductive organs.

Azee 500mg (Azithromycin 500mg) is indicated for the treatment of certain bacterial infections such as

  • bronchitis
  •  Pneumonia
  •  Sexually transmitted disease (STD)

Mechanism of Action Azee 500mg (Azithromycin 500mg)

Azee 500mg (Azithromycin 500mg) belongs to semisynthetic azalide antibiotic. It prohibits transpeptidation by connecting to 50s ribosomal subunit of affected organisms and disorganize RNA-dependent protein synthesis at the chain expansion step.

ADME of Azee 500mg (Azithromycin 500mg)

Absorption of Azee 500mg (Azithromycin 500mg)

Fastly absorbed from the GI tract. Decreased by food (capsule formulation). bioavailability: Approx 34-52%.
Duration of high plasma concentration: Oral tab: 2-3 hr;

Distribution of Azee 500mg (Azithromycin 500mg)

Volume of distribution: 31-33 L/kg.

Plasma protein binding (based on concentration): 7-51% (oral and IV). 

Metabolism of Azee 500mg (Azithromycin 500mg)

Metabolism occur in Hepatic through demethylation.

Elimination of Azee 500mg (Azithromycin 500mg)

Through bile (as unchanged medicine and inactive metabolites); urine (approx 6% of oral dose). Terminal elimination half-life: 68 hr.

Side effects of Azee 500mg (Azithromycin 500mg)

Some serious side effects is caused by Azee 500mg (Azithromycin 500mg):

  • Watery or bloody diarrhae
  • Pain in head associated with chest discomfort and severe vertigo, fainting, fast heartbeats
  • Hepatic problems – upper stomach pain, decreased appetite, dark urine, clay-colored stools, jaundice
  • Serious dermatological reaction – fever, pharyngtitis, blisters in face or tongue, burning of eyes, red or purple skin rashes.

Common side effects of Azee 500mg (Azithromycin 500mg) as follows:

  • Diarrhae
  • Nausea, vomiting, stomach pain
  • Pain in head

If these symptoms occurs call doctor immediately

Precautions of Azee 500mg (Azithromycin 500mg)

  • Susceptible to famciclovir, penciclovir cream (Denavir), acyclovir (Zovirax), any other medications, or lactose. Consult your doctor
  • Consult your doctor if you had problems with your immune system, (HIV), (AIDS); inherited conditions where the body is not able to tolerate lactose; or kidney or liver disease.
  • Consult your doctor if you are pregnant, decide to become pregnant, or are breast-feeding. While taking Virovir treatment If you become pregnant, discuss with doctor about the condition.
  • Virovir may produce drowsy, dizzy, confused, or disoriented. Avoid drive a car until reaction of medication you feel.

Contraindication of Azee 500mg (Azithromycin 500mg)

The patients using Azee 500mg (Azithromycin 500mg) is contraindicated with hypersensitivity to azithromycin and its components.
Azee 500mg (Azithromycin 500mg) using patients are contraindicated with history of liver discomfort analog to before use of azithromycin

Pregnancy of Azee 500mg (Azithromycin 500mg)

Category B: there are no studies demonstrated for fetal risk in animal reproduction and no controlled studies have been shown in pregnant women or animal reproduction in 1st trimester and later trimester there is no evidence of a risk.

Lactation of Azee 500mg (Azithromycin 500mg)

A small amount of medicine is excreted in breast milk. Use with caution while using in breast feeding mother. Please consult the doctor for further details.

Dosage of Azee 500mg (Azithromycin 500mg)

For oral dosage form

In adults for bacterial infections

500 to 2000mg once daily, administer as single dose, this may continue with 250 to 500mg dose once daily for several days

For pharyngitis or tonsillitis: 500mg on day 1 taken as single dose followed by 250mg on 2nd day through 5th day

In children’s for infections (6months age – older): based on body weight is dose and must be determined by your doctor.

10 to 30mg/kg of body weight once daily, taken as a single dose. Based on the type of infection ,continue with doses of 5 to 10 mg/kg of body weight once daily for several days.

Infants < 6 months: discuss with doctor

For pharyngitis or tonsillitis: based on body weight: 12mg/kg of body weight once daily for 5 days

< 2yrs children’s : discuss with doctor for dose.

Over dosage of Azee 500mg (Azithromycin 500mg)

If dose administer higher than prescribed dose will cause nausea, diarrhea, vomiting. If it occurs then provide general symptomatic and supportive measures are indicated as needed

Storage of Azee 500mg (Azithromycin 500mg)

Stored below 30℃

Keep away from the children

Don’t store outdated medicine

Discuss with pharmacist for the disposal of unused medicines 

Missed dose of Azee 500mg (Azithromycin 500mg)

Take the missed dose immediately before next dose reaches or skip the missed dose and follows the routine schedule. Don’t make up with extra dose. Please consult with the doctor.

Active substance:
Azithromycin
Strength:
500mg
Category:
Anti Biotic
Manufacturer:
Cipla Ltd
Packaging:
30 Tablet
Product form:
Tablet

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